Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 73)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0289671	0.0998193	0.7745133
Weighted median	23	-0.0884572	0.0583564	0.1295673
Inverse variance weighted	23	-0.0658184	0.0390153	0.0916059
Simple mode	23	-0.1166441	0.1003191	0.2573966
Weighted mode	23	-0.1166441	0.0777822	0.1479261

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.88583	21	0.5924639
Inverse variance weighted	19.04670	22	0.6424429

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022631	0.0056423	0.6924082

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006634	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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