Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 72)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0168701	0.1068787	0.8760882
Weighted median	23	0.0040336	0.0596286	0.9460675
Inverse variance weighted	23	0.0358504	0.0410924	0.3829706
Simple mode	23	0.0783084	0.1006159	0.4446883
Weighted mode	23	-0.0035493	0.0743457	0.9623539

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.07510	21	0.2894338
Inverse variance weighted	24.40435	22	0.3263966

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0032376	0.0060413	0.5976546

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007651	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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