Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 71)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2563021	0.0998180	0.0179389
Weighted median	23	-0.0895697	0.0619673	0.1483356
Inverse variance weighted	23	-0.1046256	0.0390146	0.0073249
Simple mode	23	-0.1348958	0.1047313	0.2111232
Weighted mode	23	-0.0986815	0.0776768	0.2172097

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.56341	21	0.6131245
Inverse variance weighted	21.28873	22	0.5029608

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093146	0.0056423	0.1136458

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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