Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 70)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0457046	0.1194007	0.7057276
Weighted median	23	-0.0403209	0.0576923	0.4846174
Inverse variance weighted	23	0.0356665	0.0461870	0.4399853
Simple mode	23	-0.0539935	0.0915291	0.5612647
Weighted mode	23	-0.0425764	0.0650006	0.5192478

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.04673	21	0.0910530
Inverse variance weighted	30.83107	22	0.0996245

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004997	0.0067491	0.4672597

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009595	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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