Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 7)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 0.0170627 0.0998193 0.8659106
Weighted median 23 -0.0859590 0.0607109 0.1568120
Inverse variance weighted 23 -0.0543200 0.0390153 0.1638391
Simple mode 23 -0.1798975 0.1193886 0.1460818
Weighted mode 23 -0.1243958 0.0905294 0.1832516

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 19.05072 21 0.5818865
Inverse variance weighted 19.65433 22 0.6046525

Test for directional horizontal pleiotropy

egger_intercept se pval
-0.0043836 0.0056423 0.4458683

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0006543 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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