Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 69)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0047075	0.1012128	0.9633425
Weighted median	23	0.0251956	0.0573656	0.6605087
Inverse variance weighted	23	-0.0080076	0.0390153	0.8373822
Simple mode	23	0.0309882	0.0980913	0.7550467
Weighted mode	23	0.0596436	0.0751049	0.4355980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.59007	21	0.4234525
Inverse variance weighted	21.60922	22	0.4834096

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007808	0.005721	0.8927381

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006561	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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