Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 68)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0229788	0.1092694	0.8354648
Weighted median	23	0.0181522	0.0614140	0.7675580
Inverse variance weighted	23	-0.0054838	0.0417569	0.8955170
Simple mode	23	-0.1692761	0.1299576	0.2061999
Weighted mode	23	0.0790090	0.0799923	0.3340350

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.16449	21	0.2401100
Inverse variance weighted	25.20075	22	0.2875711

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010744	0.0061765	0.8635739

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007642	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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