Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 67)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0465829	0.1024393	0.6539645
Weighted median	23	0.0437659	0.0558077	0.4329067
Inverse variance weighted	23	0.0340591	0.0391350	0.3841375
Simple mode	23	0.0696078	0.0834302	0.4130671
Weighted mode	23	0.0545562	0.0620399	0.3887036

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.11613	21	0.3928446
Inverse variance weighted	22.13471	22	0.4518734

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007691	0.0057904	0.8955991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006938	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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