Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 66)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0294755	0.0998203	0.7706757
Weighted median	23	-0.0079080	0.0545241	0.8846823
Inverse variance weighted	23	-0.0181232	0.0390158	0.6422830
Simple mode	23	-0.0247755	0.0845978	0.7723722
Weighted mode	23	-0.0286048	0.0672526	0.6747244

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.07385	21	0.5165880
Inverse variance weighted	20.08911	22	0.5774654

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006971	0.0056423	0.9028419

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006153	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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