Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 65)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0022071	0.0998202	0.9825684
Weighted median	23	0.0000022	0.0523385	0.9999666
Inverse variance weighted	23	-0.0292209	0.0390157	0.4538870
Simple mode	23	-0.0783436	0.0817379	0.3482399
Weighted mode	23	0.0150202	0.0667788	0.8241137

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.32772	21	0.6910590
Inverse variance weighted	17.41416	22	0.7401026

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016589	0.0056423	0.7716345

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005447	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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