Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 64)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2522403	0.0998196	0.0196004
Weighted median	23	-0.1066344	0.0574309	0.0633480
Inverse variance weighted	23	-0.0275005	0.0427404	0.5199445
Simple mode	23	-0.0534409	0.0921794	0.5679742
Weighted mode	23	-0.1136514	0.0613085	0.0772306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.41857	21	0.4949045
Inverse variance weighted	26.40167	22	0.2348362

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0138013	0.0056423	0.0233369

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008151	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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