Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 62)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0903434	0.1147946	0.4400736
Weighted median	23	0.0394235	0.0596501	0.5086683
Inverse variance weighted	23	-0.0256709	0.0450773	0.5690267
Simple mode	23	-0.0570057	0.1067478	0.5986815
Weighted mode	23	0.0125793	0.0771038	0.8718916

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.77328	21	0.1466993
Inverse variance weighted	29.36764	22	0.1346609

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071244	0.0064887	0.2846493

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000903	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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