Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 61)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1446246	0.1291926	0.2755895
Weighted median	23	-0.1901595	0.0625672	0.0023714
Inverse variance weighted	23	-0.1087620	0.0494418	0.0278212
Simple mode	23	-0.1485030	0.1143330	0.2074401
Weighted mode	23	-0.1942748	0.0821336	0.0272469

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.17932	21	0.0269817
Inverse variance weighted	35.33169	22	0.0357614

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022024	0.0073027	0.7659381

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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