Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 60)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1009837	0.1419195	0.4845696
Weighted median	23	-0.0418975	0.0565792	0.4589900
Inverse variance weighted	23	-0.0226060	0.0553386	0.6829038
Simple mode	23	-0.0504830	0.0846290	0.5569162
Weighted mode	23	-0.0409904	0.0541701	0.4572580

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.45046	21	0.0036918
Inverse variance weighted	44.25990	22	0.0032905

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075895	0.0080218	0.3548538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013511	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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