Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 6)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1819629	0.0998200	0.0825870
Weighted median	23	0.0490106	0.0533339	0.3581276
Inverse variance weighted	23	0.0449629	0.0390156	0.2491428
Simple mode	23	0.0749300	0.0888559	0.4081496
Weighted mode	23	0.0876350	0.0654979	0.1945693

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.85183	21	0.9655951
Inverse variance weighted	13.07517	22	0.9310436

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084132	0.0056423	0.1508083

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004365	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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