Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 59)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0113448	0.0998201	0.9105929
Weighted median	23	-0.0076451	0.0552589	0.8899636
Inverse variance weighted	23	-0.0011363	0.0390155	0.9767655
Simple mode	23	-0.0432327	0.1031632	0.6792276
Weighted mode	23	0.0635681	0.0747249	0.4041029

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.91901	21	0.9643409
Inverse variance weighted	10.93136	22	0.9757141

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006269	0.0056424	0.9125863

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003313	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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