Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 58)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0683962	0.0998198	0.5007136
Weighted median	23	0.0849595	0.0536364	0.1131961
Inverse variance weighted	23	0.0233359	0.0390155	0.5497618
Simple mode	23	0.1187421	0.0984049	0.2403751
Weighted mode	23	0.1099350	0.0708252	0.1348824

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.58507	21	0.4845205
Inverse variance weighted	20.82560	22	0.5315380

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027671	0.0056423	0.6289142

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006419	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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