Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 57)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0392035	0.0998203	0.6984690
Weighted median	23	-0.0119182	0.0559311	0.8312584
Inverse variance weighted	23	0.0562498	0.0390156	0.1493795
Simple mode	23	0.0079932	0.1000142	0.9370229
Weighted mode	23	-0.0151139	0.0724553	0.8366828

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.61505	21	0.7341603
Inverse variance weighted	16.64947	22	0.7823993

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010468	0.0056423	0.8545948

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005675	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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