Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 56)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0332862	0.1056452	0.7558138
Weighted median	23	-0.0265816	0.0575076	0.6439178
Inverse variance weighted	23	-0.0583984	0.0411878	0.1562332
Simple mode	23	-0.0535343	0.1042664	0.6127628
Weighted mode	23	-0.0215799	0.0634835	0.7371331

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.52226	21	0.3167769
Inverse variance weighted	24.51801	22	0.3206739

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0056303	0.0059716	0.3564758

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008108	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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