Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 55)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0725654	0.0998207	0.4752789
Weighted median	23	-0.0523517	0.0551922	0.3428579
Inverse variance weighted	23	0.0135854	0.0390156	0.7276874
Simple mode	23	-0.0397315	0.1014923	0.6992134
Weighted mode	23	-0.0643820	0.0633908	0.3208422

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.72751	21	0.7274860
Inverse variance weighted	17.60668	22	0.7290367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052905	0.0056423	0.3590878

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005372	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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