Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 54)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0683266	0.0998199	0.5011452
Weighted median	23	0.0772028	0.0571170	0.1764840
Inverse variance weighted	23	0.0825901	0.0390155	0.0342725
Simple mode	23	0.0416010	0.0928373	0.6584579
Weighted mode	23	0.0592947	0.0744112	0.4340531

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.45789	21	0.9264239
Inverse variance weighted	12.48199	22	0.9466106

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008759	0.0056423	0.8781139

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000514	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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