Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 53)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0626641	0.0998210	0.5369252
Weighted median	23	-0.0523379	0.0560869	0.3507382
Inverse variance weighted	23	-0.0262085	0.0390157	0.5017475
Simple mode	23	-0.0670822	0.0859207	0.4432725
Weighted mode	23	-0.0694620	0.0698570	0.3308659

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.17875	21	0.9022339
Inverse variance weighted	13.33618	22	0.9233592

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022387	0.0056424	0.6955385

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004178	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8