Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 51)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0064353	0.1319656	0.9615675
Weighted median	23	-0.0098148	0.0633711	0.8769174
Inverse variance weighted	23	-0.0022349	0.0504004	0.9646305
Simple mode	23	0.0618368	0.1276130	0.6327745
Weighted mode	23	-0.0477681	0.0951876	0.6207718

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.7049	21	0.0181953
Inverse variance weighted	36.7138	22	0.0254237

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005324	0.0074594	0.9437717

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011126	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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