Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 50)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1411897	0.1161797	0.2377504
Weighted median	23	0.0107279	0.0602589	0.8586987
Inverse variance weighted	23	-0.0378671	0.0472342	0.4227340
Simple mode	23	-0.0326133	0.1119319	0.7735000
Weighted mode	23	0.0253240	0.0725491	0.7303635

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.44762	21	0.1279070
Inverse variance weighted	32.24553	22	0.0733053

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109959	0.006567	0.108882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010056	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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