Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 5)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0046793	0.1130220	0.9673670
Weighted median	23	0.0062957	0.0581097	0.9137247
Inverse variance weighted	23	0.0254423	0.0432459	0.5563190
Simple mode	23	0.1220365	0.1091104	0.2754318
Weighted mode	23	-0.0369276	0.0716632	0.6114874

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.92243	21	0.1734355
Inverse variance weighted	27.02991	22	0.2100927

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018498	0.0063885	0.7750048

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000832	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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