Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 49)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0373037	0.0998207	0.7123687
Weighted median	23	0.0825285	0.0532281	0.1210295
Inverse variance weighted	23	0.0792349	0.0390156	0.0422701
Simple mode	23	0.0352547	0.0937523	0.7104879
Weighted mode	23	0.0625372	0.0653530	0.3490091

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.51151	21	0.6164442
Inverse variance weighted	18.71979	22	0.6625620

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002575	0.0056423	0.6528094

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006922	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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