Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 48)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0855178	0.0998200	0.4012703
Weighted median	23	0.0487541	0.0565207	0.3883636
Inverse variance weighted	23	-0.0230709	0.0391744	0.5559101
Simple mode	23	0.0457771	0.0914406	0.6216098
Weighted mode	23	0.0457771	0.0634825	0.4784435

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.78287	21	0.4722710
Inverse variance weighted	22.17967	22	0.4492093

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0066684	0.0056423	0.2504714

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006827	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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