Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 47)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0509525	0.1134391	0.6579159
Weighted median	23	-0.0158585	0.0589018	0.7877482
Inverse variance weighted	23	-0.0148790	0.0437271	0.7336535
Simple mode	23	0.0069079	0.0997200	0.9453979
Weighted mode	23	0.0034391	0.0655635	0.9586401

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.12112	21	0.1668800
Inverse variance weighted	27.63449	22	0.1881128

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040427	0.0064121	0.535183

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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