Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 46)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0493521	0.1133004	0.6675811
Weighted median	23	-0.0192340	0.0593830	0.7460155
Inverse variance weighted	23	-0.0185460	0.0433559	0.6688249
Simple mode	23	0.0231619	0.1199554	0.8486618
Weighted mode	23	-0.0395647	0.0774379	0.6144949

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.05481	21	0.1690464
Inverse variance weighted	27.16723	22	0.2049438

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0018918	0.0064043	0.7705921

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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