Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 44)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1311904	0.1066629	0.2323160
Weighted median	23	0.1052971	0.0561233	0.0606314
Inverse variance weighted	23	0.0534051	0.0413358	0.1963641
Simple mode	23	0.0499187	0.0921734	0.5935546
Weighted mode	23	0.0936187	0.0647537	0.1623388

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.97804	21	0.2941237
Inverse variance weighted	24.69478	22	0.3118921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047768	0.0060291	0.4370513

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008051	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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