Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 43)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1014185	0.1054678	0.3471898
Weighted median	23	-0.0061855	0.0545548	0.9097282
Inverse variance weighted	23	0.0133379	0.0415936	0.7484594
Simple mode	23	-0.0014424	0.0931966	0.9877913
Weighted mode	23	-0.0125734	0.0594367	0.8344110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.44358	21	0.3207913
Inverse variance weighted	25.00355	22	0.2969048

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070471	0.0059615	0.2503763

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007612	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8