Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 42)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0043249	0.1085512	0.9685956
Weighted median	23	-0.0880927	0.0585036	0.1321273
Inverse variance weighted	23	-0.0251535	0.0415384	0.5448150
Simple mode	23	0.0794508	0.1064946	0.4635320
Weighted mode	23	-0.0806411	0.0751889	0.2951144

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.83447	21	0.2544043
Inverse variance weighted	24.93741	22	0.3000772

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018103	0.0061358	0.7708671

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007682	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8