Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 41)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1261613	0.1019206	0.2294371
Weighted median	23	0.0169283	0.0572470	0.7674543
Inverse variance weighted	23	0.0078248	0.0403681	0.8463043
Simple mode	23	0.0359571	0.0953889	0.7098202
Weighted mode	23	0.0144083	0.0639566	0.8238387

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.89323	21	0.4056849
Inverse variance weighted	23.55206	22	0.3711392

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007267	0.005761	0.2209941

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007149	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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