Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 40)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0183311	0.1269754	0.8865867
Weighted median	23	0.0344903	0.0603091	0.5673945
Inverse variance weighted	23	0.0023256	0.0485098	0.9617633
Simple mode	23	-0.1453632	0.1193921	0.2363022
Weighted mode	23	0.0262406	0.0692788	0.7084912

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.97991	21	0.0364192
Inverse variance weighted	34.01025	22	0.0490065

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009829	0.0071772	0.8923778

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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