Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 4)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0090273	0.0998191	0.9287973
Weighted median	23	0.0029211	0.0557436	0.9582086
Inverse variance weighted	23	0.0578834	0.0390152	0.1379124
Simple mode	23	-0.0601729	0.1107110	0.5922417
Weighted mode	23	-0.0651787	0.0976041	0.5112154

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.31471	21	0.6918615
Inverse variance weighted	17.59746	22	0.7295700

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030003	0.0056423	0.600482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005999	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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