Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 39)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0458667	0.1181385	0.7017424
Weighted median	23	0.0814251	0.0572350	0.1548391
Inverse variance weighted	23	0.0199569	0.0451747	0.6586544
Simple mode	23	0.1064189	0.0975067	0.2869054
Weighted mode	23	0.0783375	0.0638717	0.2329827

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.41487	21	0.1043921
Inverse variance weighted	29.49440	22	0.1312797

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015911	0.0066777	0.8139801

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009017	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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