Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 38)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0184057	0.1369225	0.8943473
Weighted median	23	0.0315187	0.0648963	0.6271952
Inverse variance weighted	23	0.0315523	0.0524824	0.5477090
Simple mode	23	0.2024840	0.1539096	0.2018535
Weighted mode	23	0.1863638	0.1329217	0.1748508

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.51488	21	0.0085138
Inverse variance weighted	39.81054	22	0.0113759

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003068	0.0077397	0.6958119

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012261	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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