Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 37)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2145115	0.0998200	0.0434502
Weighted median	23	0.0794202	0.0543774	0.1441429
Inverse variance weighted	23	0.0902158	0.0390156	0.0207610
Simple mode	23	0.0737354	0.0779385	0.3543880
Weighted mode	23	0.0842911	0.0594600	0.1703134

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.39901	21	0.9282144
Inverse variance weighted	14.22912	22	0.8931483

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007633	0.0056423	0.190502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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