Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 36)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0126800	0.0998197	0.9001261
Weighted median	23	-0.0421802	0.0635626	0.5069458
Inverse variance weighted	23	0.0015608	0.0390153	0.9680893
Simple mode	23	-0.1203092	0.1183227	0.3203062
Weighted mode	23	-0.0925660	0.0826661	0.2748939

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.14468	21	0.5121140
Inverse variance weighted	20.15933	22	0.5730739

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006828	0.0056423	0.904826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006109	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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