Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 35)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1187348	0.1107346	0.2957777
Weighted median	23	-0.0310259	0.0602452	0.6065571
Inverse variance weighted	23	0.0015231	0.0436653	0.9721751
Simple mode	23	0.0830654	0.1149115	0.4773787
Weighted mode	23	-0.0095621	0.0702582	0.8929802

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.84345	21	0.2124814
Inverse variance weighted	27.55657	22	0.1908458

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007385	0.0062592	0.2512511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008351	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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