Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 34)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0700504	0.0998206	0.4905324
Weighted median	23	0.0223166	0.0577617	0.6992327
Inverse variance weighted	23	0.0270354	0.0390156	0.4883484
Simple mode	23	0.0104017	0.0971519	0.9157065
Weighted mode	23	0.0420319	0.0756655	0.5841601

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.59694	21	0.5469039
Inverse variance weighted	19.81612	22	0.5945407

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026415	0.0056423	0.6444895

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000615	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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