Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 33)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2030738	0.1006412	0.0565701
Weighted median	23	0.1101500	0.0553049	0.0464056
Inverse variance weighted	23	0.0857724	0.0398719	0.0314606
Simple mode	23	0.1414215	0.1037848	0.1867829
Weighted mode	23	0.1171154	0.0623206	0.0735243

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.34696	21	0.4379378
Inverse variance weighted	22.97689	22	0.4030355

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072035	0.0056887	0.2192832

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008427	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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