Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 32)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3480387	0.0998165	0.0021998
Weighted median	23	0.0731888	0.0589365	0.2143014
Inverse variance weighted	23	0.0692682	0.0418663	0.0980243
Simple mode	23	-0.1148765	0.1329557	0.3968991
Weighted mode	23	0.1996170	0.0951046	0.0475220

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.12766	21	0.7624361
Inverse variance weighted	25.33403	22	0.2813692

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0171197	0.0056422	0.0063082

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008631	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8