Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 31)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0880594	0.1247633	0.4880617
Weighted median	23	-0.0337634	0.0607446	0.5783301
Inverse variance weighted	23	-0.0146720	0.0481046	0.7603643
Simple mode	23	-0.1092480	0.1044614	0.3069989
Weighted mode	23	-0.0558969	0.0651816	0.4003831

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.80649	21	0.0484074
Inverse variance weighted	33.44447	22	0.0558893

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045067	0.0070522	0.5297004

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010177	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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