Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 30)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0032898	0.1419795	0.9817329
Weighted median	23	0.0985252	0.0677512	0.1458848
Inverse variance weighted	23	0.0493401	0.0543784	0.3642233
Simple mode	23	0.1384580	0.1173510	0.2506564
Weighted mode	23	0.1302107	0.1186319	0.2842467

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.48760	21	0.0036520
Inverse variance weighted	42.73883	22	0.0050809

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002828	0.0080255	0.7280677

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013435	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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