Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 3)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1114088	0.1028953	0.2912002
Weighted median	23	0.0352550	0.0610889	0.5638646
Inverse variance weighted	23	0.0053854	0.0406909	0.8947085
Simple mode	23	0.0603928	0.1249705	0.6336881
Weighted mode	23	0.1191757	0.1125550	0.3011685

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.31450	21	0.3815850
Inverse variance weighted	23.93042	22	0.3508875

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0071724	0.0058162	0.2311358

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007257	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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