Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 29)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0714016	0.1175133	0.5499648
Weighted median	23	-0.0076651	0.0602074	0.8986932
Inverse variance weighted	23	0.0447462	0.0449402	0.3194036
Simple mode	23	-0.0593064	0.1097108	0.5942347
Weighted mode	23	-0.0252022	0.0792756	0.7535545

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.10497	21	0.1115042
Inverse variance weighted	29.18913	22	0.1395398

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016369	0.0066425	0.8077406

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009243	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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