Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 28)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0359729	0.0998201	0.7221644
Weighted median	23	0.0639364	0.0545424	0.2411033
Inverse variance weighted	23	0.0724136	0.0390155	0.0634509
Simple mode	23	0.0652544	0.0923211	0.4870978
Weighted mode	23	0.0562864	0.0663690	0.4055248

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.20666	21	0.5082070
Inverse variance weighted	20.36396	22	0.5602844

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022378	0.0056423	0.6956538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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