Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 27)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1172633	0.1348197	0.3942550
Weighted median	23	0.0788806	0.0624974	0.2068981
Inverse variance weighted	23	0.0585603	0.0517571	0.2578686
Simple mode	23	-0.0485475	0.1252771	0.7020946
Weighted mode	23	0.0612218	0.0793869	0.4488034

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.30925	21	0.0118540
Inverse variance weighted	38.71747	22	0.0152006

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003605	0.0076207	0.6410585

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012415	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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