Two sample MR report

Telomere_length against rfMRI connectivity (ICA25 edge 26)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0051512	0.0998212	0.9593315
Weighted median	23	0.0284740	0.0525717	0.5880792
Inverse variance weighted	23	0.0118003	0.0390157	0.7623091
Simple mode	23	-0.0387054	0.0872587	0.6616844
Weighted mode	23	0.0341026	0.0616424	0.5856833

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.70738	21	0.8818372
Inverse variance weighted	13.74142	22	0.9104020

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001041	0.0056424	0.855395

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004192	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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